1. Contact your veterinarian for advice.
  2. In severe cases, your veterinarian may instruct you to induce vomiting, however, do not induce vomiting unless instructed to.
  3. For mild cases, your pet may not require any treatment except close monitoring at home for any changes as this drug has a wide safety margin.
  4. If your pet is demonstrating severe irritation to the flea die-off, seek veterinary attention as mild sedation may be required.




Clinical signs occur within 2 hours of treatment.

  • Hypersalivation
  • Lethargy
  • Vomiting
  • Increased breathing rate


Nitenpyram is a neorutoxin which kills fleas by inhibiting central nervous system, resulting in paralysis and death of the insect. Nitenpyram is generally safe for use in pets including pregnant or nursing animals, however, very high doses can cause toxicity.


BSAVA (2011) BSAVA Small Animal Formulary 7thEdn. Ramsey I (ed.) Gloucester: BSAVA

Wismer T & Means C (2012) Toxicology of newer insecticides in small animals. Veterinary Clinics of North America Small Animal Practice. 42(2):335-347